The transcription factor YY 2 has less momentous properties of an intrinsically disordered protein than its paralog YY 1
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چکیده
منابع مشابه
Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD
TEAD (TEA/ATTS domain) transcription factors are the most distal effectors of the Hippo pathway. YAP (Yes-associated protein) is a coactivator protein which, upon binding to TEAD proteins, stimulates their transcriptional activity. Since the Hippo pathway is deregulated in various cancers, designing inhibitors of the YAP:TEAD interaction is an attractive therapeutic strategy for oncology. Under...
متن کاملIntrinsically disordered protein.
Proteins can exist in a trinity of structures: the ordered state, the molten globule, and the random coil. The five following examples suggest that native protein structure can correspond to any of the three states (not just the ordered state) and that protein function can arise from any of the three states and their transitions. (1) In a process that likely mimics infection, fd phage converts ...
متن کاملCharacterization of brainstem peptide YY (PYY) neurons.
Peptide YY (PYY), a member of the NPY superfamily of peptides, is predominantly synthesized by the colon and is thought to act on both the gut and brain to modulate energy homeostasis. Although neurons expressing PYY mRNA have also been reported in the brainstem, little is known about their physiological role and study of their projections has been problematic due to crossreactivity of PYY anti...
متن کاملIt is not necessarily YY 1 — the frequently forgotten
de Nigris et al. (1) performed an interesting study on the functional implication of YY1 in the VEGF regulatory network, leading to a rationale for using YY1 as a therapeutic target molecule in cancer therapy. However, considering the application of YY1 for antiangiogenic treatment bears a fundamental risk because the observed effects are not necessarily specific for YY1: the YY1 antibody (C-20...
متن کاملPeptide YY(1-36) and peptide YY(3-36): Part II. Changes after gastrointestinal surgery and bariatric surgery.
Peptide YY (PYY) is secreted as a 36 amino acid, straight chain polypeptide, and is found in greatest concentrations in the terminal ileum, colon and rectum. After secretion, dipeptidyl peptidase IV (DPP-IV) cleaves the N-terminal Tyrosine-Proline residues from PYY(1-36), producing PYY(3-36). PYY(1-36) acts at all four human Y receptors, Y1, Y2, Y4 and Y5, while PYY(336) is a specific Y2 recept...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2019
ISSN: 0014-5793,1873-3468
DOI: 10.1002/1873-3468.13457